CANCER ASSIGNMENT: Selection of drugs for antineoplastic therapy

1) Present the major advances made in oncology in the last few decades.


2) Briefly, describe the major factors used for selection of drugs for antineoplastic therapy.

3) Compare the criteria used for primary versus adjuvant therapy selection.


4) Give your rationale why combination therapy is commonly used for neoplastic diseases treatment.


5) Briefly, present the mechanisms of action of antineoplastic drugs.


6) Briefly present the comparison of therapeutic effects of alkylating agents, antimetabolites, antibiotics, plant alkaloids and others.


7) Give your rationale why patients can respond favorably to antitumor drugs, but later develop a resistance.

8) Based on the pharmacokinetics of neoplastic drugs, briefly, discuss why the majority of drugs have to be administered intravenously.


9) Present the major or typical undesirable side effects of the use of antineoplastic drugs.

10) Explain why adjuvant antineoplastic drugs are becoming more common in the treatment of neoplastic diseases.

11) Briefly, present the most significant achievements of using biological therapies.

12) Briefly, present the mechanism of action of hormonal agents used for neoplastic therapies. Use examples of breast and prostate cancers.

13)What are major clinical problems related to biological therapies?

14)What are current strategies regarding vaccines use for antineoplastic therapy?

15) Briefly, present the mechanism of action of inhibitors of intracellular signaling used for antineoplastic therapy.

16) Briefly, present the benefits of clinical use and differences in the pharmacokinetics of antimetabolites for antineoplastic therapy.

17) Briefly, present the most common clinical problems related to antineoplastic therapy.