Alkylating agents: They are cell-cycle independent drugs, means they can work at any point in the cell cycle. They bind covalently to DNA with the help of their alkyl groups. The cell becomes unable to replicate crosslinked DNA. This leads to apoptosis. Antimetabolites: –  Unlike alkylating agents, anti-metabolites are cell cycle dependent. Many of them … Continue reading Briefly present the comparison of therapeutic effects of alkylating agents, antimetabolites, antibiotics, plant alkaloids and others.